NFL Week 6 Inactives: Kyler Murray OUT for Cardinals vs Colts | Full Injury Report & Analysis (2025)

The NFL's Injury Bug Bites Hard in Week 6: Kyler Murray Sidelines Cardinals' Hopes

Week 6 of the NFL season is shaping up to be a test of depth and resilience for several teams, as key players find themselves on the sidelines due to injuries. But here's where it gets controversial: Are teams doing enough to protect their star players, or is the league's physicality simply too demanding? Let's dive into the early inactives list and explore the implications.

Kyler Murray’s Absence Casts Shadow Over Cardinals’ Struggles

In a season already marked by challenges, the Arizona Cardinals face another setback as quarterback Kyler Murray is officially out for their game against the Indianapolis Colts. Murray’s foot injury, which kept him out of two practice sessions this week, has proven too severe for him to take the field. This absence comes at a critical time, as the Cardinals aim to halt a three-game losing streak. And this is the part most people miss: Without Murray’s dynamic playmaking ability, the offense may struggle to find its rhythm, putting even more pressure on backup Jacoby Brissett and the recently signed Kedon Slovis.

Inactives Across the League: A Tale of Missing Stars

The Cardinals aren’t the only team dealing with significant absences. Here’s a breakdown of the key inactives for Week 6:

  • Cardinals at Colts: Alongside Murray, the Cardinals will be without CB Elijah Jones, DL Darius Robinson, OL Demontray Jacobs, OL Josh Fryar, WR Xavier Weaver, and DL Bilal Nichols. The Colts, meanwhile, will miss RB Tyler Goodson, CB Kenny Moore, TE Will Mallory, WR Adonai Mitchell, QB Anthony Richardson, T Luke Tenuta, and DE JT Tuimoloau.

  • Rams at Ravens: The Rams’ list includes WR Tutu Atwell, LB Omar Speights, G Beaux Limmer, T Rob Havenstein, TE Colby Parkinson, and DE Deshaun Johnson. The Ravens will be without QB Lamar Jackson, LB Roquan Smith, CB Chidobe Awuzie, FB Pat Ricard, T Carson Vinson, WR Tez Walker, and DT Aeneas Peebles.

  • Cowboys at Panthers: The Cowboys are missing WR CeeDee Lamb, OL Tyler Booker, WR KaVontae Turpin, LB Jack Sanborn, DL Mazi Smith, and OL Ajani Cornelius. The Panthers’ inactives include TE Ja’Tavion Sanders, CB Akayleb Evans, RB Chuba Hubbard, S Trevian Thomas, T Taylor Moton, DT Jaden Crumedy, and DT Tershawn Wharton.

  • Seahawks at Jaguars: The Seahawks will be without QB Jalen Milroe, S Julian Love, CB Devon Witherspoon, CB Riq Woolen, LB Derick Hall, OL Josh Jones, and TE Nick Kallerup. The Jaguars’ list features S Kahlef Hailassie, RB Cody Schrader, LB Yasir Abdullah, OL Robert Hainsey, and DT Khalen Saunders.

  • Chargers at Dolphins: The Chargers’ inactives include WR Quentin Johnston, WR Derius Davis (knee), FB/DL Scott Matlock, OL Jamaree Salyer, T Joe Alt, OL Trey Pipkins, and CB Nikko Reed. The Dolphins will miss QB Quinn Ewers, RB Jaylen Wright, CB Storm Duck, DT Zeek Biggers, LB Tyrel Dodson, WR Cedrick Wilson Jr., and DB Elijah Campbell.

  • Patriots at Saints: The Patriots’ list includes QB Tommy Devito, S Jaylinn Hawkins, LB Anfernee Jennings, DT Eric Gregory, G Caedan Wallace, and DE Keion White. The Saints will be without S Ugo Amadi, CB Rejzohn Wright, OL Torricelli Simpkins, OL Xavier Truss, DT Khristian Boyd, and CB Isaac Yiadom.

  • Browns at Steelers: The Browns’ inactives feature CB Jarrick Bernard-Converse, RB Raheim Sanders, DT Mike Hall Jr., T Thayer Munford, G Zak Zinter, and T Cornelius Lucas. The Steelers will miss WR Calvin Austin, S Chuck Clark, DL DeMarvin Leal, DL Logan Lee, and OL Andrus Peat.

The Bigger Picture: Injury Prevention and Player Longevity

While injuries are an inevitable part of football, the frequency and severity of these absences raise questions about player safety and team strategies. Here’s a thought-provoking question for you: Should the NFL implement stricter rules to protect players, or is the current approach sufficient? Share your thoughts in the comments below. As we watch these games unfold, it’s clear that the teams with the deepest rosters and most adaptable strategies will have the edge in this physically demanding season.

NFL Week 6 Inactives: Kyler Murray OUT for Cardinals vs Colts | Full Injury Report & Analysis (2025)

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